Explanation in Causal Inference: Methods for Mediation and Interaction

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Explanation in Causal Inference: Methods for Mediation and Interaction Description

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The book provides an accessible but comprehensive overview of methods for mediation and interaction. There has been considerable and rapid methodological development on mediation and moderation/interaction analysis within the causal-inference literature over the last ten years. Much of this material appears in a variety of specialized journals, and some of the papers are quite technical. There has also been considerable interest in these developments from empirical researchers in the social and biomedical sciences. However, much of the material is not currently in a format that is accessible to them. The book closes these gaps by providing an accessible, comprehensive, book-length coverage of mediation.

The book begins with a comprehensive introduction to mediation analysis, including chapters on concepts for mediation, regression-based methods, sensitivity analysis, time-to-event outcomes, methods for multiple mediators, methods for time-varying mediation and longitudinal data, and relations between mediation and other concepts involving intermediates such as surrogates, principal stratification, instrumental variables, and Mendelian randomization. The second part of the book concerns interaction or "moderation," including concepts for interaction, statistical interaction, confounding and interaction, mechanistic interaction, bias analysis for interaction, interaction in genetic studies, and power and sample-size calculation for interaction. The final part of the book provides comprehensive discussion about the relationships between mediation and interaction and unites these concepts within a single framework. This final part also provides an introduction to spillover effects or social interaction, concluding with a discussion of social-network analyses.

The book is written to be accessible to anyone with a basic knowledge of statistics. Comprehensive appendices provide more technical details for the interested reader. Applied empirical examples from a variety of fields are given throughout. Software implementation in SAS, Stata, SPSS, and R is provided. The book should be accessible to students and researchers who have completed a first-year graduate sequence in quantitative methods in one of the social- or biomedical-sciences disciplines. The book will only presuppose familiarity with linear and logistic regression, and could potentially be used as an advanced undergraduate book as well..


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Principles and Practice of Clinical Research, Third Edition

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Principles and Practice of Clinical Research, Third Edition Description

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The third edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers.

• Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical Research
• Addresses the vast opportunities for translation of basic science observations to the bedside through clinical research
• Delves into data management and addresses how to collect data and use it for discovery
• Contains valuable, up-to-date information on how to obtain funding from the federal government

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Guidelines for Cardia Rehabilitation and Secondary Prevention Programs-5th Edition With Web Resource

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Guidelines for Cardia Rehabilitation and Secondary Prevention Programs-5th Edition With Web Resource La revue

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Guidelines for Cardiac Rehabilitation and Secondary Prevention Programs, Fifth Edition With Web Resource, covers the entire scope of practice for cardiac rehabilitation and secondary prevention (CR/SP) programs. This text was developed by the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR) and parallels federal guidelines for cardiac rehabilitation programs. It contains information on promoting positive lifestyle behavior patterns, reducing risk factors for disease progression, and lessening the impact of cardiovascular disease on quality of life, morbidity, and mortality.

The text has been updated and restructured, providing the most current models for designing and updating rehabilitation programs for patients and preventing second episodes. In addition to chapter revisions, there is new content on behavior modification, risk factors, and special populations. The chapter covering program administration has been completely rewritten to include new regulations and reimbursement standards as well as additional suggestions for new models for CR/SP. The most recent Core Competencies for Cardiac Rehabilitation and Secondary Prevention Professionals and the Core Components of Cardiac Rehabilitation/Secondary Prevention Programs have also been included in their entirety.

More than 50 leaders in the field of CR/SP, cardiovascular risk reduction, reimbursement, and public policy have contributed the latest tools and information, enabling cardiac rehabilitation professionals to successfully start new programs or update and enhance existing ones. Key features of the fifth edition include the following:

• A new web resource incorporates 24 questionnaires, charts, consent forms, protocols, records, checklists, and logs from the text that can be used when creating or assessing programs.

• Highlighted guidelines in each chapter cover current issues and provide hints and methods for implementing treatment programs and helping patients stay on track.

• Chapter objectives and summaries help readers quickly assess the topics covered and identify the most important points.

There is strong evidence that participation in outpatient cardiac rehabilitation and secondary prevention programs decreases mortality and recurrent morbidity after a cardiac event. Guidelines for Cardiac Rehabilitation and Secondary Prevention Programs, Fifth Edition, offers procedures for providing patients with low-cost, high-quality programming, moving them toward personal responsibility for disease management and secondary prevention over a lifetime. This is the definitive resource for developing inpatient and outpatient cardiac rehabilitation programs.

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